‘Wanximai 0638’ is a new weak gluten wheat variety bred by Lu’an Academy of Agricultural Sciences. To explore the high-yield cultivation techniques in the suitable sowing area and guide the cultivation of the variety for large-scale promotion, the authors set up 8 kinds of nitrogen fertilizer management methods and carried out experiments in 24 plots. The results showed that under the nitrogen application rate of 234 kg/hm², and basal/topdressing ratio of 7:3:3 for base fertilizer + striking root fertilizer + jointing fertilizer, the plant height of ‘Wanximai 0638’ was too high and the lodging area reached 50.00%. Under the nitrogen application rate of 288 kg/hm², and the basal/topdressing ratio of 7:3:3:3 for base fertilizer + seedling fertilizer + striking root fertilizer + jointing fertilizer, the lodging rate of ‘Wanximai 0638’ was 81.67%, and the grain quality of ‘Wanximai 0638’ could not meet the standard of weak gluten wheat. Using the nitrogen application rate of 180 kg/hm², and basal/topdressing ratio of 7:3 for basal fertilizer + striking root fertilizer, the large area lodging could be avoided, higher yield could be obtained, and the quality of weak gluten in ‘Wanximai 0638’ grains could be guaranteed.