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Two experiments (Experiment I and II) were established to evaluate the effects of water depth and culture net on survival and growth of pearl oyster Pinctada maxima from June 2010 to June 2011, with an aim to improve growth traits of the stocks. Four groups were set in Experiment I: HA, 3 m; HB, 6 m; HC, 9 m; and HD, 12 m. Three groups were set in Experiment II: BN, box net; CN, cone net; and LN, cylinder net. At days 90, 180, 270, 360, survival and growth of the groups in Experiment I and II were compared. In Experiment I, there were insignificant differences in survival rate among the four groups at days 90, 180, 270 (P>0.05). At days 360, the survival rate among the four groups differed significantly (P<0.05). The HD group had the largest survival rate at days 90, 180, 270 and 360. Insignificant differences in mean shell height and total weight among the four groups were observed (P>0.05). In Experiment II, survival rate among the BN, CN and LN groups were insignificant at days 90 and 180 (P>0.05). At days 270 and 360, however, the difference in survival rate among the three groups was significant (P<0.05). The LN group had the largest survival rate at days 90, 180, 270 and 360. At days 90, 180 and 270, mean shell height and total weight differed insignificantly among the three groups (P>0.05). Differences in mean shell height and total weight were significant (P<0.05). The LN group displayed the largest mean shell height and total weight at days 90, 180, 270 and 360. The present results suggested that optimal water depth and culture net was 6-9 m and cylinder net suspended in the sea.