This study aims to explore the new model, path and methodology of the informatization service for farmers’ science popularization in the background of implementing the Rural Revitalization Strategy, and to provide reference for constructing agricultural informatization service system and supporting rural revitalization at all levels nationwide. Based on the literature research of agricultural science popularization and its new model and methodology, the authors analyzed the experience of building 12316 Sannong (namely agriculture, rural community and farmers) Comprehensive Information Service Platform in Liaoning Province and the platform’s actual role in supporting rural revitalization. Liaoning 12316 Sannong Comprehensive Information Service Platform has created a new ‘five in one’ model of science popularization informatization service for farmers, with a structure of 5 levels of national, provincial, municipal, county and township. From 2019 to 2021, the platform provided 11.3071 million cases of science popularization service within Liaoning Province, and it has now become a typical model of ‘Internet + Agriculture’ application in the province and a key brand of agricultural informatization. The platform can provide reference for local agricultural departments to improve their informatization service system construction, and the basic infrastructure construction should be highlighted for building agricultural information network to cultivate farmers with high capacity. It is suggested that the provincial level agricultural information service platform should establish a ‘galaxy’ model of science popularization service system to carry out cross-region science popularization activities, and agricultural information service platforms at all levels should actively explore diversified informatization service models to support rural revitalization.