Study on the Acute Toxicity of Theaflavins and Theaflavins Tablet

Chinese Agricultural Science Bulletin ›› 2014, Vol. 30 ›› Issue (21) : 285-288. DOI: 10.11924/j.issn.1000-6850.2013-3081
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Study on the Acute Toxicity of Theaflavins and Theaflavins Tablet

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Abstract

The acute toxicity properties of theaflavins and theaflavins tablet was carried out to evaluate by acute toxicity test method. The results showed that, the female mouse acute oral LD50 oftheaflavins extracts was 2710.0mg/kg body weight, which was 136 times to 271 times of adultdaily dose (10mg/kg to 20mg/kg) . The male mice acute oralLD50 of theaflavins extracts was 3160.0mg/kg body weight, which was 158 times to 316 times of adult daily dose (10mg/kg to 20mg/kg). The female mice acute oralLD50 of theaflavinstablet was 20000.0mg/kg body weight, which was 400 times to 500 times of adult daily dose (40mg/kg to 50mg/kg) . The male mice acute oral LD50 of theaflavinstablet was 14700.0mg/kg body weight, which was 294 times to 368 times of adult daily dose (40mg/kg to 50mg/kg) . In a word, the male mice and female mouse acute oral LD50 of theaflavins extracts and theaflavins tablet were more than 100 times of adult dosage. It illustrated that the theaflavin extract and theaflavins tablet have less toxic, and was In accordance with the acute toxicity evaluation standards of health food.

Key words

theaflavins; theaflavins tablet; toxicology; acute toxicity; median lethal dose

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Study on the Acute Toxicity of Theaflavins and Theaflavins Tablet. Chinese Agricultural Science Bulletin. 2014, 30(21): 285-288 https://doi.org/10.11924/j.issn.1000-6850.2013-3081

References

[1] Ying Gao, Wei Li, Lingyan Jia, et al. Enhancement of ( ?)- epigallocatechin- 3- gallate and theaflavin- 3- 3′- digallate induced apoptosis by ascorbic acid in human lung adenocarcinoma SPC-A-1 cells and esophageal carcinoma Eca-109 cells via MAPK pathways [J]. Biochemical and Biophysical Research Communications,2013, 438(2):370-374.
[2] Gaurav Kumar, Prerana Dange, Vaishali Kailaje, et al. Polymeric black tea polyphenols modulate the localization and activity of 12- O-tetradecanoylphorbol-13-acetate-mediated kinases in mouse skin: Mechanisms of their anti- tumor- promoting action[J]. Free Radical Biology and Medicine,2012,53(6):1358- 1370.
[3] Korir M W, Wachira F N, Wanyoko J K, et al. The fortification of tea with sweeteners and milk and its effect on in vitro antioxidant potential of tea product and glutathione levels in an animal model [J]. Food Chemistry,2014,145:145-153.
[4] Lakshi Prasad Bhuyan, Santanu Sabhapondit, Binoti Devi Baruah, et al. Polyphenolic compounds and antioxidant activity of CTC black tea of North-East India[J]. Food Chemistry,2013,141(4):3744- 3751.
[5] Xiao- Yu Luo, Terumi Takahara, Jiangang Hou et al. Theaflavin attenuates ischemia–reperfusion injury in a mouse fatty liver model [J]. Biochemical and Biophysical Research Communications,2012, 417(1):287-293.
[6] Yoshitaka Hosokawa, Ikuko Hosokawa, Satoru Shindo, et al. Black tea polyphenol inhibits CXCL10 production in oncostatin Mstimulated human gingival fibroblasts[J]. International Immunopharmacology,2011,11(6):670-674.
[7] Mian Zu, Fan Yang, Weiling Zhou, et al. In vitro anti- influenza virus and anti- inflammatory activities of theaflavin derivatives[J]. Antiviral Research,2012,94:217-224.
[8] ie Yang, Lin Li, Suiyi Tan, et al. A natural theaflavins preparation inhibits HIV- 1 infection by targeting the entry step: Potential applications for preventing HIV- 1 infection[J]. Fitoterapia,2012,83 (2):348-355.
[9] Ming Miao, Huan Jiang, Bo Jiang, Elucidation of structural difference in theaflavins for modulation of starch digestion[J]. Journal of Functional Foods,2013,5(4):2024-2029.
[10] Duiyan Jin, Yi Xu, Xin Mei, et al. Antiobesity and lipid lowering effects of theaflavins on high-fat diet induced obese rats[J]. Journal of Functional Foods,2013,5(3):1142-1150.
[11] Annadurai Anandhan, Kuppusamy Tamilselvam, Thangaiyan Radhiga, et al. Theaflavin, a black tea polyphenol, protects nigral dopaminergic neurons against chronic MPTP/probenecid induced Parkinson's disease[J]. Brain Research,2012,1433:104-113.
[12] Anandhan A, Janakiraman U, Manivasagam T. Theaflavin ameliorates behavioral deficits, biochemical indices and monoamine transporters expression against subacute 1- methyl- 4- phenyl-1,2,3,6-tetrahydropyridine(MPTP)-induced mouse model of Parkinson’ s disease[J]. Neuroscience,2012,218:257-267.
[13] Betts J W, Kelly S M, Haswell S J. Antibacterial effects of theaflavin and synergy with epicatechin against clinical isolates of Acinetobacter baumannii and Stenotrophomonas maltophilia[J]. International Journal of Antimicrobial Agents,2011,38(5):421-425 .
[14] 张建勇,江和源,崔宏春,等.氧气对茶多酚化学氧化合成茶黄素的影响[J].食品与发酵工业,2011,37(4):58-62.
[15] 刘冬英,傅颖,梅松,等.茶多酚的毒理学安全性评价[J].毒理学杂志, 2009,33(1):87-88.
[16] 王岳飞,梁善珠,张士康,等.茶多酚抗辐射制剂安全毒理学研究[J].茶叶科学,2011,31(5):405-410.
[17] 谭俊峰,林智,李靓.茶氨酸复合制剂安全性毒理学研究[J].食品科学,2011,32(9):262-267.
[18] 中国疾病预防控制中心营养与食品安全所.GB15193.1—2003,食品安全性毒理学评价程序和方法[S].北京:中国标准出版社,2003.
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