Transgenic results showed that DREB/CBF transcription factors had important application value for improvement of plant stress-resistant breeding. In this study, by using of crossbreeding, CBF3 was transferred into rice indica strong restorer line, and the effect of CBF3 on the agronomic characters of the progenies of F2 restorer line under drought condition were studied. The results indicated that, the agronomic characters of transgenic rice 3 with CBF3 and nontransgenic rice 5 had little difference under drought condition, but in the cross between transgenic rice 3, nontransgenic rice 5 and indica strong restorer line, the agronomic characters of F2 made a great difference under drought condition, parts materials, such as 9311 etc., were manifested as that plant height increased significantly, the grain number per panicle, filled grain number per panicle, 1000-grain weight and grain weight per plant etc. decreased significantly, but another parts, such as OP193 etc., showed with fine combining ability in the number of effective panicle, 1000-grain weight, grain weight per plant etc. The study provided a reference for the further research in the new indica hybrid rice varieties breeding, which was with CBF3, and showed as super drought tolerance.