In order to understand the occurrence regularity and influence factors of winter wheat freeze injury in Cangzhou area, by methods of consulting the temperature history data and statistical analysis, the interannual variation regularity of temperature conditions during wheat over-wintering stage was studied in Cangzhou area for 1970-2009. The results showed that, the indicators, including accumulated temperature before winter, autumn temperature cooling rate, annual negative accumulated temperature, January extreme high temperature and spring temperature cooling rate, differed significantly. In some years, adverse extreme values of one or several indicators might trigger a wheat freeze injury. Except the significantly positive correlation between annual negative accumulated temperature and January extreme high temperature, the other correlation between indicators was not significant. The fluctuation of accumulated temperature before winter and autumn temperature cooling rate occurred in different decades. These results had a certain reference value for in-depth understanding of wheat freezing injury regularity in this area.