For exploration of the measures and techniques in inhibiting the uptake of Cd by rice plants and protecting the hygienic quality of rice grains in the polluted soil environment, a study was made on the effects of organic acid and EDTA on quality of different genotypes rice in cadmium polluted soil through a pot experiments, the result showed that cadmium significantly increased Cadmium content of rice gains and reduced protein content, starch and crude grease of rice gains with Cd level increasing, In cadmium polluted soil, organic acid, EDTA reduced cadmium content in rice gains. EDTA reduces cadmium content of gains in a big way, next is organic acid+1/2EDTA; effect of organic acid is weaker. Organic acid, EDTA enhanced protein content of rice gains in cadmium-polluted soil, the order as follows: EDTA > organic acid, organic acid+1/2EDTA.Organic acid, EDTA decreased contents of starch and crude grease of rice gains in cadmium-polluted soil, and EDTA gave best effect. In cadmium-polluted soil, effect of organic acid+1/2EDTA on quality of rice was better than organic acid, EDTA.Ⅱ527 was more easily obtained high yield and excellent quality than high grain Cd accumulation Xiushui 63 in cadmium polluted soil.