In order to research the feasibility of moderate reduction fertilization in Chaohu Lake basin, a field experiment was conducted to study the effects of reducing fertilizer with amino acids in water-soluble fertilizer and trace element fertilizer application on tomato production, quality and NPK absorption. The results showed that: reducing fertilizer with amino acids in water-soluble fertilizer and trace element fertilizer was not only to ensure stable production of tomato, but also played an active role in promoting to tomato taste and growth. Compared with custom fertilization, 85% fertilizer, 75% fertilizer could make tomato production increase, the rate separately were 24.3%, 3.8%, the rate which 65% fertilizer made the production down was 8.2%; it could make the nitrate content in tomato fruit reduce, the percentage separately were 9.01%, 6.12%, 10.44%. The rate which made the nitrate content down in 0-20 cm soil horizon after tomato harvest separately were 58.34%, 15.00%, 40.99%; the ratio which made the available P content lower in 0-20 cm soil horizon after tomato harvest separately were 32.04%, 31.72%, 30.69%. 85% fertilizer had the best treatment effect, achieved the purpose of tomato yield and reduced the nutrient loss.