Hexi corridor is one of the most serious areas of desertification. The special geographical environment and the arid climate factors are the natural background of regional land desertification development. Unreasonable human activities and the contradiction relationship of human and earth are the internal source of aggravation of desertification extended. Analysis of the desertification situation of the Hexi corridor showed that: three drainage area of the Hexi corridor would be regarded as three eco-economic systems and be unified planed and systemic treated: adjust the regional structure of industry; develop the agriculture style of water saving and establish ecological economy model. The technology support would be strengthened on the desertification control and the related research of desertification was widely developing to promote the benefit of the desertification. Meanwhile, it would eliminate the effect of human factor by improving population quality and people’s life condition, solving the outstanding problems of economic and social development.