Hepatocyte nuclear factor-4α (HNF-4α) is a member of the hepatocyte nuclear factor family,can be highly expressed in the liver,The family of genes regulating the differentiation of liver cells play a key role,while involved in liver glucose and lipid metabolism in the regulation of specific gene expression.HNF-4α gene involved in regulating many aspects of life and metabolic activity in animals play an important role in growth and development. In this study, PCR-SSCP method to analyze the HNF-4α gene single nucleotide polymorphisms associated with growth traits. The results showed that polymorphisms of SH1 BB genotype individuals for French Landrace effect of birth length was the highest. SH2 polymorphic loci on the legal systems of AB genotype in Landrace the effect of individual birth weight of the maximum value. At the same time, the site with a large public histological properties of porcine muscle fiber there are significant correlation. AB-type individual muscle fiber diameter and muscle fiber cross-sectional area was significantly lower than AA and BB type (P <0.05).