The study was carried out by using the principle of agricultural systems engineering and the qualified design of three factor square saturated D, in which the factors of sowing date (x1), sowing quantity (x2), amount of fertilizer application (x3) were taken as the adjusting factors, and the yield (y) of each hm2, as target function, Though the study we got a mathematic model for high-yield and good-quality ecological cultivation of wheat in irrigation region. The result indicated that, under the condition of this experiment design, factors affecting wheat yield in irrigation region were in order as sowing date x1> sowing quantity x2> amount of fertilizer application x3 when the target yield was from 7500～9000kg/hm2,the optimum formula of wheat high-yield and good quality in irrigation region was as follows: sowing date x1 from 2nd to 5th October, sowing quantity x2of 145.91～211.76×104 seed/hm2,fertilizer application x3 of pure N、P（N∶P2O5=1∶1）191.83～304.73 kg/hm2。This study provides a scientific foundation for high-yield and good quality ecological cultivation of wheat in irrigation region.