为了优化平贝母中总生物碱的提取工艺，采用中心组合设计方法，研究乙醇浓度、超声时间、液固比及其交互作用对总生物碱提取率的影响。应用SAS软件和响应面分析相结合的方法，模拟得到回归方程的预测模型和可信度，并通过岭脊分析得到最佳的提取条件为：乙醇浓度81.4%、超声时间74.9 min、液固比30.9 mL/g。该条件下提取率为0.158%。该实验研究，为平贝母总生物碱的工业化生产提供了必要的技术支持。

To optimize the extraction technique for total alkaloids from Bulbus Fritillariae ussurionsis, the effects of ethanol concentration, ultrasonic extraction time, the liquid to solid ratio and their interaction on extraction rate were studied by central composite design. The predictive model and reliability were developed by SAS software and response surface analysis. The optimal ultrasonic extraction conditions were achieved and listed as follows: ethanol concentration 81.4%, ultrasonic extraction time 74.9 min, the liquid to solid ratio 30.9 mL/g, through ridge analysis. Under the optimum conditions, the extraction yield of total xanthones was 0.158%. The necessary technical support was provided by this experimental study for the industrial production of total alkaloids from Bulbus Fritillariae ussurionsis.