Impact of plant polyphenols on triacylglycerols and phospholipids in rat liver fed with high fat diet

Huifang Ma, Ya Xie, Chen Yang, Fang Wei, Chao Hu, Zongyuan Wu, Zong Yang, Xin Lyu, Xuyan Dong, Hong Chen, Fenghong Huang

油料作物学报(英文版). 2017, 2(04): 251-264

油料作物学报(英文版) ›› 2017, Vol. 2 ›› Issue (04) : 251-264. DOI: 10.1016/j.ocsci.2016-0048

Impact of plant polyphenols on triacylglycerols and phospholipids in rat liver fed with high fat diet

  • Huifang Ma, Ya Xie, Chen Yang, Fang Wei, Chao Hu, Zongyuan Wu, Zong Yang, Xin Lyu, Xuyan Dong, Hong Chen, Fenghong Huang
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Impact of plant polyphenols on triacylglycerols and phospholipids in rat liver fed with high fat diet

  • Huifang Ma, Ya Xie, Chen Yang, Fang Wei, Chao Hu, Zongyuan Wu, Zong Yang, Xin Lyu, Xuyan Dong, Hong Chen, Fenghong Huang
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摘要

The effect of plant(rapeseed and grape seed) polyphenols on lipid metabolism of rat fed with high fat diet was studied. 30 rats were divided into 5 groups including group Z(basal diet), C(high fat diet without plant polyphenol), S(high fat diet with rapeseed polyphenols), R(high fat diet with grape seed polyphenols) and F(combined with rapeseed and grape seed polyphenols). Levels of lipids including TAGs and PLs in rats were investigated by shotgun-electrospray ionization tandem mass spectrometry(shotgun-ESI-MS). Results showed that high fat diet would give rise to the total TAGs and decreased total phosphatidylcholine(PC), phosphatidylethanolamine(PE) and phosphatidylserine(PS)(p < 0.05) in group C, S, R and F, compared with group Z. Results also showed that supplementary with rapeseed polyphenols or grape seed polyphenols reduced total TAGs and increased total PC, PE and PS(p < 0.05) in group S, R and F, compared with group C. Grape seed polyphenols and rapeseed polyphenols had certain regulatory effect on metabolism diseases such as fatty liver.

Abstract

The effect of plant(rapeseed and grape seed) polyphenols on lipid metabolism of rat fed with high fat diet was studied. 30 rats were divided into 5 groups including group Z(basal diet), C(high fat diet without plant polyphenol), S(high fat diet with rapeseed polyphenols), R(high fat diet with grape seed polyphenols) and F(combined with rapeseed and grape seed polyphenols). Levels of lipids including TAGs and PLs in rats were investigated by shotgun-electrospray ionization tandem mass spectrometry(shotgun-ESI-MS). Results showed that high fat diet would give rise to the total TAGs and decreased total phosphatidylcholine(PC), phosphatidylethanolamine(PE) and phosphatidylserine(PS)(p < 0.05) in group C, S, R and F, compared with group Z. Results also showed that supplementary with rapeseed polyphenols or grape seed polyphenols reduced total TAGs and increased total PC, PE and PS(p < 0.05) in group S, R and F, compared with group C. Grape seed polyphenols and rapeseed polyphenols had certain regulatory effect on metabolism diseases such as fatty liver.

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Huifang Ma, Ya Xie, Chen Yang, Fang Wei, Chao Hu, Zongyuan Wu, Zong Yang, Xin Lyu, Xuyan Dong, Hong Chen, Fenghong Huang. Impact of plant polyphenols on triacylglycerols and phospholipids in rat liver fed with high fat diet. 油料作物学报(英文版). 2017, 2(04): 251-264 https://doi.org/10.1016/j.ocsci.2016-0048
Huifang Ma, Ya Xie, Chen Yang, Fang Wei, Chao Hu, Zongyuan Wu, Zong Yang, Xin Lyu, Xuyan Dong, Hong Chen, Fenghong Huang. Impact of plant polyphenols on triacylglycerols and phospholipids in rat liver fed with high fat diet. Oil Crop Science. 2017, 2(04): 251-264 https://doi.org/10.1016/j.ocsci.2016-0048

基金

supported by the National Natural Science Foundation of China(Grant No.31571926;; supported by the Agricultural Science and Technology Innovation Project of Chinese Academy of Agricultural Sciences(CAAS-ASTIP-2013-OCRI);; Central Public-interest Scientific Institution Basal Research Fund of Ministry of Agriculture(1610172016005)

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