In order to screened suitable plant growth regulators and foliar fertilizers for winter wheat production, the effectiveness, yield, and economic benefits of spraying different plant growth regulators and foliar fertilizer combinations on winter wheat in controlling Fusarium head blight were analyzed. The results showed that applying different growth regulators and foliar fertilizers during the early flowering stage of winter wheat could achieve an increase of 1.92% to 31.74% in the control effect of Fusarium head blight in years with severe Fusarium head blight, an increase of 3.84% to 16.97% in yield, and increased economic benefits. The degree of increase in yield and efficiency of different combinations of growth regulators and foliar fertilizers varies. Among them, the combination of 0.25% 28-Epibrassinolide·S-showantin and foliar fertilizer potassium dihydrogen phosphate had the best effect, which could be used to improve the tillering and ear formation rate of wheat, and increase the thousand grain weight and yield of wheat. The combination of 28-Epimerosal·Gibberellanic acid and foliar fertilizer potassium dihydrogen phosphate（0.4%） had the second best effect, and could be used as a rotation agent.