Abstract
Anti-inflammatory effects of different extracts of Fomitopsis pinicola fruiting bodies were investigated by xyleneinduced ear swelling test and acetic acidinduced peritoneal capillary permeability test in mice. The antiinflammatory mechanisms were studied via determination of serum levels of superoxide dismutase (SOD) and Malondialdehyde (MDA), as well as tissue levels of SOD, MDA, prostaglandin E2 (PGE2) and tumor necrosis factorα (TNFα). The analgesic effects were assessed by acetic acidinduced writhing and hot plateinduced pain in mice. The antipyretic activities were explored using dry yeastinduced rat fever and endotoxininduced rat fever models. The results showed that, compared with the model group, water extract and nbutanol extract (high polarity extracts) of F. pinicola significantly reduced peritoneal capillary permeability, acetic acidinduced writhing and hot plate pain response in mice, and the body temperature in rat fever models induced by yeast or endotoxin (P<0.01 or P<0.05), followed by methanol extract (P<0.05). Methylene chloride and petroleum ether extracts significantly reduced xyleneinduced ear swelling in mice (P<0.01), and significantly increased SOD levels in mouse sera and right ear tissues (P<0.01 or P<0.05), and significantly decreased the levels of MDA in mouse sera and MDA and PGE2 in right ear tissues (P<0.01 or P<0.05). The results indicated the antiinflammatory, analgesic and antipyretic effects of F. pinicola fruiting body extracts. The bioactive compounds were mainly concentrated in the highly polar water and nbutanol extracts, followed by methanol extracts.
Key words
Fruiting body /
extract /
anti-inflammatory /
analgesia /
antipyretic
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ZHAO Xiuhong, BAO Haiying.
Study on Anti-inflammatory, Analgesic and Antipyretic Activities of Extracts of Fomitopsis pinicolaFruiting Bodies. Acta Edulis Fungi. 2019, 26(03): 82-90 https://doi.org/10.16488/j.cnki.1005-9873.2019.03.010
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