Study on Anti-inflammatory, Analgesic and Antipyretic Activities of Extracts of Fomitopsis pinicolaFruiting Bodies

ZHAO Xiuhong, BAO Haiying

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PDF(878 KB)
Acta Edulis Fungi ›› 2019, Vol. 26 ›› Issue (03) : 82-90. DOI: 10.16488/j.cnki.1005-9873.2019.03.010
Original Paper

Study on Anti-inflammatory, Analgesic and Antipyretic Activities of Extracts of Fomitopsis pinicolaFruiting Bodies

  • ZHAO Xiuhong, BAO Haiying
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Abstract

Anti-inflammatory effects of different extracts of Fomitopsis pinicola fruiting bodies were investigated by xyleneinduced ear swelling test and acetic acidinduced peritoneal capillary permeability test in mice. The antiinflammatory mechanisms were studied via determination of serum levels of superoxide dismutase (SOD) and Malondialdehyde (MDA), as well as tissue levels of SOD, MDA, prostaglandin E2 (PGE2) and tumor necrosis factorα (TNFα). The analgesic effects were assessed by acetic acidinduced writhing and hot plateinduced pain in mice. The antipyretic activities were explored using dry yeastinduced rat fever and endotoxininduced rat fever models. The results showed that, compared with the model group, water extract and nbutanol extract (high polarity extracts) of F. pinicola significantly reduced peritoneal capillary permeability, acetic acidinduced writhing and hot plate pain response in mice, and the body temperature in rat fever models induced by yeast or endotoxin (P<0.01 or P<0.05), followed by methanol extract (P<0.05). Methylene chloride and petroleum ether extracts significantly reduced xyleneinduced ear swelling in mice (P<0.01), and significantly increased SOD levels in mouse sera and right ear tissues (P<0.01 or P<0.05), and significantly decreased the levels of MDA in mouse sera and MDA and PGE2 in right ear tissues (P<0.01 or P<0.05). The results indicated the antiinflammatory, analgesic and antipyretic effects of F. pinicola fruiting body extracts. The bioactive compounds were mainly concentrated in the highly polar water and nbutanol extracts, followed by methanol extracts.

Key words

Fruiting body / extract / anti-inflammatory / analgesia / antipyretic

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ZHAO Xiuhong, BAO Haiying. Study on Anti-inflammatory, Analgesic and Antipyretic Activities of Extracts of Fomitopsis pinicolaFruiting Bodies. Acta Edulis Fungi. 2019, 26(03): 82-90 https://doi.org/10.16488/j.cnki.1005-9873.2019.03.010
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