Guifei mango has bright color and sweet taste, which is deeply loved by consumers. However, the yield and economic benefits of this mango had been seriously affected due to a high fruit abortion rate. Forchlorfenuron (CPPU) is a swelling agent used in the mango industry of Hainan which can improve fruit setting rate, promote fruit enlargement and induce parthenocarpy. But, the abuse of CPPU resulted in a higher percentage of abnormal fruit, the decline of quality, stay-green after harvest and flavor change. To find a appropriate dosage, we compared the effects of CPPU spraying with different concentrations on the yield, quality, postharvest storage characteristics and incidence of disease in mango fruit. The experiment was carried out in a demonstration park of mango standardization production, Chinese Academy of Tropical Agricultural Sciences, Dongfang City, Hainan Province. The Guifei mango trees with healthy, consistent size and vigor were selected as the test material. The age of trees is about 12 years. And CPPU aqueous solutions of 10 mg/L, 20 mg/L and 60 mg/L were sprayed on 15, 25 and 35 days after full bloom, respectively. Distilled water was used as a blank treatment. Six trees were selected for each treatment (3 repetitions). The fruits were harvested at 78 days after flowering, then put into corrugated boxes to avoid damage. All the fruits were brought back to the laboratory and stored in a cold storage at (25±1)℃ and 80%-90% relative humidity (RH). Fruit color parameters (L* value, a* value, b* value) and pericarp pigments (contents of total chlorophylls, anthocyanins and carotenoids) were measured during harvest and storage to evaluate the effect of CPPU on the fruit color. Fruit firmness and contents of soluble solid content (TSS), titratable acid (TA), vitamin C were measured to evaluate the effect of CPPU on inner quality, postharvest storage characteristics and fruit ripening of mango fruit. In addition, the effects of CPPU on yield, single fruit weight of parthenocarpic fruit/pollinated and fruit-shape index were also studied. Spraying 10 mg/L CPPU solution could significantly improve the average yield (45.73 kg), 34.03% higher than the control (34.12 kg). Spraying a CPPU solution of higher concentration (20 mg/L, 60 mg/L) had no obvious effect on yield increase, or even reduced the yield. Spraying 10 mg/L CPPU solution had little effect on the number of fruits per tree. But if spraying CPPU solution of 20 mg/L and 60 mg/L could significantly reduce the number of fruits per tree by 46.08% and 60.19% compared with the control. Spraying 60 mg/L CPPU solution had the most obvious effect, the single fruit weight of pollinated and parthenocarpic fruit increased by 28.48% and 117.25% respectively. Spraying CPPU solution could increase the fruit-shape index of mango, but there was no significant difference compared with the control. Spraying CPPU had a significant effect on the contents of chlorophyll, carotenoid and anthocyanin during maturation and ripening of mango. That fruits treated with CPPU had higher chlorophyll and carotenoid content, lower anthocyanin content, and showed a greener color. The chlorophyll content in a mango peel treated with 10 mg/L, 20 mg/L, 60 mg/L CPPU increased by 5.12%, 8.67%, 9.83% and 21.23%, 36.63%, 48.07% respectively during maturation and ripening compared with the control. And the increase of carotenoid content was more obvious treated with 60 mg/L CPPU than that treated with 10 mg/L and 20 mg/L, the carotenoid content increased 22.56% and 18.81% respectively during maturation and ripening compared with the control. Different from chlorophyll and carotenoids, the content of anthocyanins decreased gradually with the increase of CPPU concentration. The content of anthocyanins decreased by 8.94%, 13.62%, 18.30% and 13.83%, 16.19% and 17.58% respectively treated with 10 mg/L, 20 mg/L, 60 mg/L CPPU during maturation and ripening compared with the control. The process of mango fruits from green to yellow was delayed by CPPU spraying during storage. Spraying CPPU solution could increase fruit firmness and titratable acidity (TA) content, reduce soluble solids content (TSS) content and delay fruit ripening. The incidence rate of anthracnose and stem-end rot decreased after CPPU treated. But in all processing, only the fruits treated with CPPU in doses of 10 mg/L were normal during fruits coloring. In addition, spraying CPPU could prolong the storage time of mango fruits, 60 mg/L CPPU treatment could delay the ripening for 4 days. Spraying 10 mg/L CPPU on 15, 25 and 35 days after full bloom stage could increase fruit-shape index, promote fruit enlargement and increase the mango yield. At the same time, the postharvest fruit treated with 10 mg/L CPPU could delay fruit softening and ripening during storage, reduce the occurrence of postharvest diseases, prolong storage time. Nevertheless, the nutritional quality of fruit was also decreased during ripening with the fruit hardness increased and the TSS content decreased. Spraying higher concentration of CPPU solution (20 mg/L, 60mg/L) had no obvious effect on yield increase, or even reduced the yield. Therefore, we suggest that spraying 10 mg/L CPPU solution in mango production, which could improve the yield, prolong the storage time and ensure the postharvest fruit quality.